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Abdomen or duodenal ulcer. If you have a abdomen ulcer or duodenal ulcer, prednisone could make it worse. Having prednisone using an NSAID (discomfort reliever) like ibuprofen may increase your chance of building or worsening an ulcer. If you have one of these ulcers, talk to your health care provider about no matter if prednisone is best for your